Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO’s Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types * Includes synonyms * Includes over 2300 references
This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.
Neuropsychobiology 2004, 50 (2), 134–143. Green, B. Focus on amisulpride. Curr. Med. Res. Opin. 2002, 18 (3), 113–117. Engelhardt, E. L.; Miller, Ch. S. Verfahren zur Herstellung von heterocyclischen Benzamiden, DE 1595915 (1965).
This text features contributions from seventeen leading medicinal and process chemists who show you how it is done.
Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen ...
The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof ...
Curran, A. C. W.; Shepherd, R. G.; J. Chem. Soc., Perkin Trans]. 1976, 983. Lesher, G. Y.; Froelich, E. J .; Gruett, M. D.; Bailey, J. H.; Brundage, R. P.; J. Med. Chem. 1962, 5, 1063. Kaminsky, D.; Meltzer, R. I.; J. Med. Chem.
This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal ...
Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from ...
This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them.
(a) Senn-Bilfinger, J.; Kruger, U.; Sturm, E.; Figala, V.; Klemm, K.; Kohl, B.; Rainer, G.; Schaefer, H.; Blake, T.J.; Darkin, D.W.; Ife, R.J.; Leach, C.A.; Mitchell, R.C.; Pepper, E.S.; Salter, C.J.; Viney, N.J.; Huttner, G.; Zsolnai, ...