This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications
( b ) Tisdale , M .; Kemp , S. D .; Parry , N. R .; Larder , B. A. Proc . Natl . ... Sucheck , S. J .; Wong , A. L .; Koeller , K. M .; Boehr , D. D .; Draker , K. - a .; Sears , P .; Wright , G. D .; Wong , C.-H. J. Am . Chem . Soc .
The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration.
It was discovered serendipitously by Alexander Fleming in 1928 that a fungus of the Penicillum family produces a material that has powerful antimicrobial activity. For that discovery, he received the Nobel Prize in Medicine in 1945 ...
This book presents the author’s own personal experience in this field and describes the "ups" and "downs" that come with drug discovery.
Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two ...
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
The Organic Chemistry of Drug Design and Drug Action
Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.
Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen ...