Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now
( a ) D = Divergence P = Polymorphism s = Synonymous a = Amino acid ( b ) Adh D. simulans vs D. yakuba P = 0.005 ( c ) ... McDonald and Kreitman realized that if polymorphisms within species are faithfully transformed into divergence ...
Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research.
This book is for undergraduate students, graduate students and professionals in biology and other sciences who require a concise but comprehensive introduction to population genetics.
This book fills a vacuum in the field and is expected to become a primary reference in Population Genomics world-wide.
Workman, P.L., Blumberg, B.S., and Cooper, A.J. (1963). Selection, gene migration and polymorphic stability in a U.S. white and negro population. American Journal of Human Genetics 15: 71–84. Wozniak, M.A., Faragher, E.B., Todd, ...
In Troublesome Science, Rob DeSalle and Ian Tattersall provide a lucid and forceful critique of how scientific tools have been misused to uphold misguided racial categorizations.
This process is known as Southern blotting, after its inventor.47 Mutations of any base in a restriction enzyme recognition sequence will lead to a failure to cleave, and conversely, mutation can sometimes create a new cleavage site; ...
This book tells the emerging story of our often surprising ancestry - the extraordinary ancient migrations and mixtures of populations that have made us who we are.
Population Genomics With R presents a multidisciplinary approach to the analysis of population genomics.
With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines.