Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available.
Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier.
Thomson JA, ItskovitzEldor J, Shapiro SS, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–1147. Chambers I, Smith A. Selfrenewal of teratocarcinoma and embryonic stem cells. Oncogene.
Genetically modified animals were created about 30 years ago, and are considered good models of human diseases.
Animal Models for the Study of Multiple Sclerosis Robert H. Miller, Sharyl Fyffe-Maricich, Andrew V. Caprariello. 51. 52. 53. 54. 55. ... Mix E, MeyerRienecker H, Hartung HP, Zettl UK. ... Kaye JF, Kerlero de Rosbo N, Mendel I, et al.
Reward behavior represents a subset of conditioning procedures that have been developed by psychologists to study learning in animals.
This chapter reviews the insights obtained into studies into KS over the past decades and highlights the contribution made by the animal model.
In this review, we compare the salient anatomy of the primate and rodent retina, particularly in the light of AMD pathology. Next, prevailing hypotheses explaining how AMD may develop are discussed.
This text provides valuable information in selecting and using suitable animal species for research so that the experimental data can be meaningful and relevant to human disease. It will be...
The current review explores two popular Pavlovian conditioning procedures, conditioned place preference and conditioned taste aversion, which are used to investigate the rewarding and aversive effects (respectively) of drugs of abuse.