This account describes the scientific events that have led from malonamides which coextract minor actinide and lanthanide fission products, to the 1,2,4-triazines such as BTBP and BTPhen reagents that are capable of separating Am(III) from Eu(III). The journey started with Mike Hudson having a walk in hot and dusty Rome with Claude Musikas of the CEA in 1980 and continues to Mike enjoying a celebratory beer (or two) in Reading (2012) with Laurence Harwood and Frank Lewis. Throughout the journey, organic synthesis, coupled with coordination chemistry, has been the engine by which successful science has developed.
This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way.
If excellent strategy is employed, poor tactics can frequently survive because the outcome is inevitable, ... In the practice of organic synthesis the above analogies are frequently true, and can perhaps be summarized by saying that a ...
In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges.
This essay addresses some of those examples in an effort to demonstrate the merits of creative risktaking in the planning and execution of organic syntheses. Keywords Risktaking; Organic synthesis; Creative strategy; Progesterone; ...
This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way.
This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges.
Organic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds.
(b)Kummer DA, Chain WJ, Morales MR, Quiroga O, Myers AG. JAm Chem Soc. 2008;130:13231–13233. 3. For selected references, see: (a) Myers, A. G.; Yang, B. H.; Chen, H.; McKinstry, L.; Kopecky, D. J.; Gleason, J. L. J. Am. Chem. Soc.
Our strategy coalesced around the idea of using a reductive epoxide ring opening/cyclization19 for constructing the pivotal C1–C9 bond. We envisaged the synthesis of a fully elaborated cyclopentane Cring (47) containing an epoxide and ...
Hart DW, Schwartz J. JAm Chem Soc. 1974;96:8115. 37. Schwartz J, Labinger JA. Angew Chem Int Ed Engl. 1976;15:333. 38. Maryanoff BE, Reitz AB. Chem Rev. 1989;89:863. 39. Evans DA, Chapman KT, Bisaha J. JAm Chem Soc. 1984;106:4261. 40.