Antibody Fc: Chapter 10. Antibody Glycosylation

Antibody Fc: Chapter 10. Antibody Glycosylation
ISBN-10
012806031X
ISBN-13
9780128060315
Series
Antibody Fc
Category
Medical
Pages
358
Language
English
Published
2013-08-06
Publisher
Elsevier Inc. Chapters
Authors
Xiaojie Yu, Kavitha Baruah, Christopher N. Scanlan

Description

The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact of glycosylation on the immune function of antibodies and discuss the implications for monoclonal antibody and intravenous immunoglobulin therapies.

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