Antibody Fc: Chapter 16. Fcγ Receptors as Therapeutic Targets
- ISBN-10
- 0128060379
- ISBN-13
- 9780128060377
- Series
- Antibody Fc
- Category
- Medical
- Pages
- 358
- Language
- English
- Published
- 2013-08-06
- Publisher
- Elsevier Inc. Chapters
- Author
- Robert M. Anthony
Description
IgG antibodies are highly potent molecules, with the unique ability to link foreign particles to innate immune cells. IgG antibodies recognize antigens with high affinity and bind cellular Fc receptors with low affinity individually. These interactions occur in the form of immune complexes, resulting in high-avidity interactions. In fact, the effector functions triggered by IgG antibodies are highly dependent on the type of Fc receptor that is bound; however, many aspects can influence Fc receptor binding by IgG antibodies, including the IgG isotype and the composition of the glycan on the IgG antibody. Further, FcγR expression is not stagnant but instead is affected by the inflammatory milieu. These considerations, and others that affect targeting of IgG Fcs to specific FcγRs to elicit desired effector functions, are discussed herein.
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Other editions
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- 2013-08-06
- 358 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-08-06
- 358 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-08-06
- 358 pages
- Ebook
- Elsevier Inc. Chapters
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