Computational Toxicology: Chapter 4. Modeling of Sensitive Subpopulations and Interindividual Variability in Pharmacokinetics for Health Risk Assessments
- ISBN-10
- 012806045X
- ISBN-13
- 9780128060452
- Series
- Computational Toxicology
- Category
- Medical
- Pages
- 274
- Language
- English
- Published
- 2013-06-04
- Publisher
- Elsevier Inc. Chapters
- Authors
- Paul White, Kannan Krishnan, Brooks McPhail
Description
Many health risk assessments develop exposure limits for chemicals, intended to protect the general population, including sensitive subpopulations. Critical toxicokinetic and toxicodynamic determinants of toxicity vary among subgroups of populations, thus making some of them potentially more susceptible than the general population to the health effects of chemicals. This chapter focuses on toxicokinetics and reviews the current computational approaches to address the issue of interindividual variability for health risk assessments. These approaches include individual-based PBPK modeling, P-bounds modeling, Monte Carlo simulation, and Markov Chain Monte Carlo simulation, each of which has different data requirements regarding input parameters. The advantage of these computational approaches is that they allow predictions of variables that cannot be easily accessed or measured in susceptible subpopulations with the available methodologies. Thus, the resulting simulations are useful in characterizing the magnitude of interindividual variability in the human health assessment of chemicals.
Get the book
Other editions
-
- 2013-06-04
- 274 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-04
- 274 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-04
- 274 pages
- Ebook
- Elsevier Inc. Chapters
Similar books
-
How Institutions are Shaping the Future of Our Children: For Better or for Worse?
By Catherine Dulmus, Karen SowersLammert, M., & Timberlake, E. M. (1986). Termination of foster care for the older adolescent: Issues of emancipation and individuation.
-
Reversibility of Chronic Disease and Hypersensitivity, Volume 5: Treatment Options of Chemical Sensitivity
By William J. Rea, Kalpana D. PatelDou, L., E. Bertrand, C. Cerini, V. Faure, J. Sampol, R. Vanholder, Y. Berland, P. Brunet. ... A. Timberlake, B. Sumpio, R. Pfragner, I. M. Modlin, M. Kidd.
-
Rockwood and Green's Fractures in Adults
By William Ricci, Charles M. Court-Brown, Margaret M. McQueenChendrasekhar A, Moorman DW, Timberlake GA. An evaluation of the effects of ... Chittiboina P, Wylen E, Ogden A, et al. Traumatic spondylolisthesis of the ...
-
Breast Pathology, An Issue of Surgical Pathology Clinics
By Laura C. CollinsHartmann LC, Radisky DC, Frost MH, et al. Understanding the premalignant potential of ... D'Alfonso TM, Wang K, Chiu YL, et al. Pathologic upgrade rates on ...
-
Telepractice in Speech-Language Pathology
By K. Todd HoustonStensland, J., Speedie, S., Ideker, M., House, J., & Thompson, T. (1999). The relative cost of outpatient ... Deal, J. L. (1987). Appraisal and diagnosis of ...
-
Addressing Adversity: Prioritising adversity and trauma-informed care for children and young people in England.
By Marc Bush, Lord Victor Adebowale, Rebecca Adlington1 2 Howard, S. and Johnson, B. (2000) Resilient and Non-resilient Behaviour in ... 4 De Haan, L., Hawley, D. and Deal, J. (2002) 'Operationalizing family ...
-
Culture, Brain, and Analgesia: Understanding and Managing Pain in Diverse Populations
By Mario Incayawar, Knox H. Todd... are not fluent in the language/s of the medical care provider.72 Research ... Anglo-Americans have traditionally placed a great deal of emphasis on the ...
-
Image-Guided Spine Interventions
By John M. MathisThis practical guide thoroughly discusses both well-established and new interventions that are applied to the spine for the purpose of pain relief.
-
New Mynursinglab -- Access Card -- For Maternal-Child Nursing (24-Month Access)
By Pearson Education, Pearson Education, Inc., David P Pearson EducationSeveral versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable.
-
Pearson's Medical Assisting (General)
By Pearson Education Staff, Madan Dr Pearson EducationIf a picture paints a thousand words, imagine what video can do? Pearson Medical Assisting Videos help users learn the nuances and the details of many medical assisting procedures.