Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components: Chapter 7. In Vivo Antileishmanial Activity of Plant-Based Secondary...

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components: Chapter 7. In Vivo Antileishmanial Activity of Plant-Based Secondary...
ISBN-10
0128066784
ISBN-13
9780128066782
Series
Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components
Category
Medical
Pages
296
Language
English
Published
2013-05-24
Publisher
Elsevier Inc. Chapters
Authors
Luiz Felipe Domingues Passero, Márcia D. Laurenti, Gabriela Santos-Gomes

Description

Leishmaniasis is an infectious disease caused by parasites belonging to the Leishmania genus. This disease has a prevalence that exceeds 12 million, and approximately 350 million individuals are currently residing in areas at risk for contracting the infection. The standard drugs employed in the treatment pose serious side effects for patients. Moreover, some reports suggested that the Leishmania species present different degrees of resistance to conventional drugs, which justifies the ongoing search for novel leishmanicidal molecules. In only a few decades, the available research pertaining to plant-derived leishmanicidal compounds has increased considerably; however, the majority of bioguided studies have only shown antileishmanial activity in vitro, thus ignoring the potential in vivo effects of different classes of plant-derived compounds on Leishmania species. This chapter will discuss the main findings of works published from 2002 to 2012 on purified plant compounds and their leishmanicidal effects in vivo.

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