Thermotaxis of the nematode Caenorhabditis elegans is a suitable behavior for the study of neural plasticity. The simple neural circuit for thermotaxis provides the guideline for information processing. Recently developed techniques for optically manipulating neuronal activity and neural imaging have facilitated the dissection of such neural processing. Thermosensory neurons remember sensed temperatures. Part of highly sophisticated and complicated information flow between sensory neurons and interneurons has also been revealed. Recent finding have revealed that evolutionally conserved molecules such as insulin, monoamines, and neuropeptides are required for the plasticity. We propose the functional analogy between the thermotaxis neural circuit and human brain structure, which may help elucidation of the in-depth circuit operation of human brain.
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