Invertebrate Learning and Memory: Chapter 20. Molecular and Cellular Mechanisms of Classical Conditioning in the Feeding System of Lymnaea
- ISBN-10
- 0128071680
- ISBN-13
- 9780128071687
- Series
- Invertebrate Learning and Memory
- Category
- Medical
- Pages
- 600
- Language
- English
- Published
- 2013-06-18
- Publisher
- Elsevier Inc. Chapters
- Author
- György Kemenes
Description
Lymnaea provides highly valuable experimental models for top-down analyses of associative learning and memory. Using classical conditioning paradigms, molecular mechanisms of consolidation, maintenance, retrieval, and reconsolidation of associative memory have been investigated. Long-term memory (LTM) forms after multitrial reward and aversive conditioning but, unusually, also after single-trial reward conditioning (“flashbulb memory”). Molecular mechanisms of LTM involve highly conserved signaling pathways (NO/cGMP, cAMP/PKA, MAPK, NMDA receptors, and CaMKII), transcriptional regulation of gene expression by CREB and C/EBP, and new protein synthesis. Cellular mechanisms of LTM involve synaptic or nonsynaptic plasticity in key modulatory interneurons of the feeding network. Importantly, a number of molecular processes involved in LTM have been traced from the behavioral level to single identified neurons.
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Other editions
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- 2013-06-18
- 600 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-18
- 600 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-18
- 600 pages
- Ebook
- Elsevier Inc. Chapters
-
- 2013-06-18
- 600 pages
- Ebook
- Elsevier Inc. Chapters
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