Invertebrate Learning and Memory: Chapter 27. Drosophila Memory Research through Four Eras: Genetic, Molecular Biology, Neuroanatomy, and Systems Neuroscience

Invertebrate Learning and Memory: Chapter 27. Drosophila Memory Research through Four Eras: Genetic, Molecular Biology, Neuroanatomy, and Systems Neuroscience
ISBN-10
0128071753
ISBN-13
9780128071755
Series
Invertebrate Learning and Memory
Category
Medical
Pages
600
Language
English
Published
2013-06-18
Publisher
Elsevier Inc. Chapters
Authors
Ronald L. Davis, Seth M. Tomchik

Description

The study of learning and memory using Drosophila melanogaster has evolved across four broad areas of investigation: genetics, biochemistry/molecular biology, neuroanatomy, and systems neuroscience. Research into the genetics of learning and memory has revealed critical signaling pathways underlying memory formation, ranging from the centrality of cAMP signaling in memory acquisition to the roles of Rac and dopamine in forgetting. Biochemistry and molecular biology have characterized the molecular functions of these signaling pathways that regulate memory. Neuroanatomical studies have established the role of the mushroom body in the encoding and retrieval of memories and identified other components of the memory circuits. Finally, circuit- and systems-level analysis have revealed how multiple sets of neurons interact to generate the functional changes in circuits that encode memories. Here, we review the progress across these domains and provide an outlook for future contributions of Drosophila to the study of learning and memory.

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