Peripheral Nerve Disorders: Chapter 26. Vasculitic neuropathy

Peripheral Nerve Disorders: Chapter 26. Vasculitic neuropathy
ISBN-10
012807857X
ISBN-13
9780128078570
Series
Peripheral Nerve Disorders
Category
Medical
Pages
1008
Language
English
Published
2013-08-17
Publisher
Elsevier Inc. Chapters
Authors
Gérard Said, Alexander F.J.E. Vrancken

Description

Vasculitis is a primary phenomenon in autoimmune diseases such as polyarteritis nodosa, Wegener’s granulomatosis, Churg–Strauss syndrome, microscopic polyangiitis, and essential mixed cryoglobulinemia. As a secondary feature vasculitis may complicate, for example, connective tissue diseases, infections, malignancies, and diabetes. Vasculitic neuropathy is a consequence of destruction of the vessel wall and occlusion of the vessel lumen of small epineurial arteries. Sometimes patients present with nonsystemic vasculitic neuropathy, i.e., vasculitis limited to peripheral nerves and muscles with no evidence of further systemic involvement. Treatment with corticosteroids, sometimes in combination with other immunosuppressants, is required to control the inflammatory process and prevent further ischemic nerve damage.

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