Overflow Metabolism: From Yeast to Marathon Runners
- ISBN-10
- 0128123354
- ISBN-13
- 9780128123355
- Category
- Medical
- Pages
- 84
- Language
- English
- Published
- 2017-10-27
- Publisher
- Academic Press
- Author
- Alexei Vazquez
Description
Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results
Get the book
Similar books
-
Allocation of Proteome Resources in E. Coli
By Sheng HuiIn this dissertation, I am interested in understanding the global strategy of proteome resources allocation and exploring its physiological consequences in E. coli.
-
Insect-Plant Interactions
By Elizabeth A. BernaysPotts, R. C. and Hewitt, P. H., The partial purification and some properties of the cellulase from the termite Trinervitermes trinervoides (Nasutitermitinae), Comp. Biochem. Physiol., 47B, 317, 1974. Potts, R. C. and Hewitt, P. H., ...
-
Physiological Stress Responses in Bioprocesses
By Sven-Olof Enfors, Thomas Eglibetter measure of metabolic burden might be the accumulation rate of the proteolytically unstable protein product or ... 7.3.6 Influence of Toxic Metabolic Products Formation of by - products of glucose by overflow metabolism or mixed ...
-
Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production
By Kazuyuki ShimizuThe book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms.
-
Amino Acid Biosynthesis – Pathways, Regulation and Metabolic Engineering
By Volker F. WendischThis book presents the current knowledge of fundamental as well as applied microbiology of amino acids.
-
Microbial Life History: The Fundamental Forces of Biological Design
By Steven A. FrankOverflow Metabolism: Mechanisms 163 overow sugar glycolysis TCA electron transport Figure 12.4 Catabolic flux and glycolytic overflow in cells capable of aerobic respiration. As sugar intake and glycolytic flux rise, cells may excrete ...
-
Metabolism and Bacterial Pathogenesis
By Tyrrell Conway, Paul S. CohenWhen NADH binds, a conformational change ensues that causes Rex to lose its ability to interact with DNA (181). In E. faecalis, deletion of the ldh gene causes the carbon overflow metabolism to be redirected toward acetoin, ethanol, ...
-
Basic Biotechnology
By Colin Ratledge, Bjorn KristiansenIn this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology.
-
Secondary Metabolism in Plant Cell Cultures
By International Association of Plant Cell and Tissue CultureThis 1986 book, derived from the meeting held by the International Association of Plant Cell and Tissue Culture in Sheffield in July 1985, describes the state of research in the area of secondary metabolism in plant cell and tissue culture.