Basic Principles of Drug Discovery and Development
- ISBN-10
- 0128172150
- ISBN-13
- 9780128172155
- Category
- Medical
- Pages
- 712
- Language
- English
- Published
- 2021-03-30
- Publisher
- Academic Press
- Author
- Benjamin E. Blass
Description
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry
Get the book
Other editions
Similar books
-
Drug Discovery and Development - E-Book: Technology in Transition
By Raymond G HillFor HTS applications, the development of the Fluorescence Imaging Plate Reader (FLIPRTM, Molecular Devices Inc., described by Schroeder and Negate, 1996), allowing the simultaneous application of reagents and test compounds to multiwell ...
-
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications
By Xiaoling LiThis book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to ...
-
Introduction to Biological and Small Molecule Drug Research and Development: Theory and Case Studies
By Stanley M. Roberts, C. Robin Ganellin, Roy JefferisThe book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches.
-
Textbook of Drug Design and Discovery, Third Edition
By Tommy Liljefors, Povl Krogsgaard-Larsen, Ulf MadsenThe book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration.
-
Drug Discovery and Development: From Targets and Molecules to Medicines
By Ramarao PoduriThis book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery.
-
Drug Design: Principles and Applications
By Abhinav GroverThis book offers an in-depth discussion of the latest strategies in the field of drug design and their applications in various disorders, in order to encourage readers to undertake their own projects.It also includes the contemporary ...
-
Cancer Drug Design and Discovery
By Stephen NeidleThe ultimate source of information on the design of new anticancer agents, emphasizing small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects.
-
Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy
By Claudio Carini, Michael R. Bleavins, Mallé Jurima-RometThis book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process.
-
The Organic Chemistry of Drug Design and Drug Action
By Richard B. SilvermanAlberts, A. W.; Chen, J.; Kuron, 6.; Hunt, V.; Huff, J.; Hoffman, C.; Rothrock, J.; Lopez, M.; Joshua, H.; Harris, E.; Patchett, A.; Monaghan, R.; ... (a) Stokker, G. E.; Rooney, C. S.; Wiggins, J. M.; Hirschfield, J. J. Org. Chem.
-
Social Aspects of Drug Discovery, Development and Commercialization
By Odilia Osakwe, Syed A.A. RizviThis book examines the scientific, legal, philosophical, economic, political, ethical and cultural factors that contribute to drug development.