Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods of Enzymology series Updated release includes the latest information on the Synthetic and Enzymatic Modifications of the Peptide Backbone
The first section of the book focusses on the design and synthesis of different bionanoparticles and hybrid structures including the use of genetic modification as well as by organic synthesis.
Then techniques are discussed yielding proteins with natural synthetic modifications. Examples discussed include nonsense ... Many enzymatic proteins are able to modify peptide side chains or the backbone. These PTMs are a way for the ...
These building blocks can then be introduced into the growing peptide chain to produce O-linked glycopeptides with one or several attachment sites of the carbohydrate to the peptide backbone. Chemo-enzymatic modifications can also occur ...
carboxypeptidases like angiotensin converting enzyme (ACE), which cleave the C-terminal dipeptide from a peptide chain. ... Introduction of steric bulk along the peptide backbone by substitution of methyl groups for o-hydrogens or amide ...
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria.
14.2.2 Synthetic Synthetic peptides are exceptional protein mimics. Synthetic peptides can be generated with diverse chemical modifications, including the introduction of nonnatural amino acids or modification of the peptide backbone.
Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites because such peptides can be ... of a large range of non-proteinogenic amino acids as well as the modification of the peptide backbone.
This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress.
... Discovery and Screening 14.1.1 A Rationale for New Methods in Drug Discovery Combinatorial chemistry has been one ... high-throughput screening (HTS) will be a key factor in realizing the potential of new drug discovery strategies ...
Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline ...