This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature
Viral dynamics in hepatitis B virus infection . Proc . Natl . Acad . Sci . USA , 93 : 4398-402 , 1996 . [ 34 ] M.A. Nowak and R.M. May . Virus Dynamics : Mathematical Principles of Immunology and Virology .
M.A.Nowak,R.M.May, Viral Dynamics: Mathematical Principles of Immunology and Virology (Oxford University Press, New York, 2000) 38. A. Boianelli, V.K. Nguyen, T. Ebensen, K. Schulze, E. Wilk, N. Sharma, S. StegemannKoniszewski, ...
Nowak M, May RM (2000) Virus dynamics: mathematical principles of immunology and virology: mathematical principles of immunology and virology. Oxford University Press, Oxford, UK 13. Baccam P et al (2006) Kinetics of infiuenza A virus ...
Neumann, A.U. (1998). Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-Therapy. Science 282, 103-107. Nowak, M.A., and May, R.M. (2000). Virus Dynamics: Mathematical Principles of Immunology and Virology.
Differential equation modeling of HIV viral fitness experiments: Model identification, model selection, ... Virus Dynamics: Mathematical Principles of Immunology and Virology: Mathematical Principles of Immunology and Virology.
The book covers first basic principles of formulating a mathematical model, and an outline on data-driven parameter estimation and model selection.
[54] J. del Castillo, B. Katz, “Interaction at end-plate receptors between different choline derivatives,” Proc. Roy. Soc. B 146 (1957), 369–381. [55] A. Chatterjee, P. Smith, A. Perelson, “Hepatitis C viral kinetics: the past, ...
Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible.
9, 618–629 (2009) M ̈uller, V., Maree, A.F., De Boer, R.J.: Release of virus from lymphoid tissue affects human ... 106, 1–21 (1991) Nowak, M.A., May, R.M.: Virus dynamics: Mathematical Principles of Immunology and Virology.
Virus Dynamics: Mathematical Principles of Immunology and Virology. Oxford University Press (2000). Nowak MA, Anderson RM, McLean AR, Wolfs TF, Goudsmit J, May RM. Antigenic diversity thresholds and the development of AIDS. Science.