This is the first volume to make available specific case histories of therapeutic proteins and peptides that have been marketed or are currently under clinical testing. The editors have selected a wide range of molecules derived from monoclonal antibodies, recombinant DNA, and natural and chemical sources to provide formulation scientists with practical examples of the deveopment of pharmaceutical products.
... factor , Proc . Natl . Acad . Sci . USA 84 : 7841–7845 . Marion , D. , and Wüthrich , K. , 1983 , Application of ... DeMarco , A. , and Kaptein , R. , 1986b , Photo - CIDNP nuclear magnetic resonance as a probe for conformational changes ...
This volume reviews protein stability and the analytical and biophysical characterization of proteins. It emphasizes drug delivery approaches, especially local delivery through the skin. Including both academic and industrial perspectives...
... Stability characterization and formulation development of Alteplase, a recombinant tissue plasminogen activator, in: Stability and Characterization of Protein and Peptide Drugs: Case Histories, 5 (Y. J. Wang and R. Pearlman, eds ...
The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules ...
A new method for building protein conformations from sequence alignments with homologs of known structure . J Mol Biol 217 : 1-7 , 1991 . 60 . ... An automated method of modeling proteins on known templates using distance geometry .
This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies.
This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
Formulation, Characterization, and Stability of Protein Drugs
This comprehensive volume brings the different aspects of peptide and protein formulation into focus, beginning with the fundamentals of the production of peptides and proteins, ranging from peptide synthesis and recombinant DNA technology ...
Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therap