This issue of Surgical Pathology Clinics, edited by Dr. Sean R. Williamson, will focus on Genitourinary Pathology. Topics include, but are not limited to, Large ductal lesions of the prostate; Update in hereditary renal cancer; Urothelial carcinoma variants; Non-germ cell tumors of the testis; Prostate cancer (grading); Prostate cancer (staging); Renal cancer; Testis grading and staging; Bladder grading and staging; "Man from Istanbul" lesions of the genitourinary tract; Mesenchymal tumors of genitourinary tract; Translational molecular updates in renal cancer; Pathologic reporting parameters most relevant to the urologist; and Pathologic reporting parameters most relevant to the medical oncologist.