Genomics: The Science and Technology Behind the Human Genome Project
- ISBN-10
- 0471461865
- ISBN-13
- 9780471461869
- Series
- Genomics
- Category
- Science
- Pages
- 596
- Language
- English
- Published
- 2004-01-06
- Publisher
- John Wiley & Sons
- Authors
- Charles R. Cantor, Cassandra L. Smith
Description
A unique exploration of the principles and methods underlying theHuman Genome Project and modern molecular genetics andbiotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the HumanGenome Project, and Cassandra L. Smith give the first integraloverview of the strategies and technologies behind the Human GenomeProject and the field of molecular genetics and biotechnology.Written with a range of readers in mind-from chemists andbiologists to computer scientists and engineers-the book beginswith a review of the basic properties of DNA and the chromosomesthat package it in cells. The authors describe the three maintechniques used in DNA analysis-hybridization, polymerase chainreaction, and electrophoresis-and present a complete exploration ofDNA mapping in its many different forms. By explaining both thetheoretical principles and practical foundations of modernmolecular genetics to a wide audience, the book brings thescientific community closer to the ultimate goal of understandingthe biological function of DNA. Genomics features: Topical organization within chapters for easy reference A discussion of the developing methods of sequencing, such assequencing by hybridization (SBH) in which data is read throughwords instead of letters Detailed explanations and critical evaluations of the manydifferent types of DNA maps that can be generated-includingcytogenic and restriction maps as well as interspecies cellhybrids Informed predictions for the future of DNA sequencing
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