Medicinal Chemistry: An Introduction, provides a comprehensive, balanced introduction to this exciting, evolving and multi-disciplinary field. This text assumes little prior knowledge of medicinal chemistry and keeps the approach as simple as possible. Focusing on the chemical principles used for drug discovery and design, it also covers human biology where relevant. Each chapter has a summary of its contents, self-assessment questions, numerous examples and applications.
NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * ...
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
Emphasizing applications of chemistry while reinforcing theory -- especially in the areas of organic and physical chemistry -- this new text prepares students for career success in the pharmaceutical, medical, and biotech industries.
This book aims to be their practical handbook - a complete guide to the drug discovery process.
These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges.
This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities...
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical ...
For many years, we stayed confident that solid‐phase combinatorial chemistry was one of them, and we believe that today this is more the case ... Combinatorial Strategies in Biology and Chemistry, John Wiley & Sons, ltd., West Sussex.
Another piece of the puzzle concerning the role of GR in RA is the discovery of a natural existing splice variant of GR, the GR. This protein represents a truncated version of GR (GR), that can translocate to the nucleus and bind to ...