Rising to the LEAP Challenge: Case Studies of Integrative Pathways to Students Signature Work is a series of case studies that reflect the "real-world" application of students' cumulative learning through signature work projects, as put forth in the LEAP Challenge. Such projects focus on complex questions that are meaningful to individual students and to society; require students to integrate, apply, demonstrate, reflect on, and communicate their cumulative learning; and require input from multiple disciplines and perspectives. Colleges and universities can best prepare students to accomplish signature work through guided-pathway curricula and cocurricular experiences in which students can develop and connect their knowledge and skills across broad and specialized study over time. The thirteen case studies included in Rising to the LEAP Challenge demonstrate the variety of forms signature work can take, as well as the institutional contexts and curricular pathways that can effectively support it. The cases are specifically tailored to provide practical advice for campus leaders seeking to design, implement, and assess integrative pathways to student signature work.