Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry.
NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * ...
This book aims to be their practical handbook - a complete guide to the drug discovery process.
Whether you are just starting your education toward a career in a healthcare field or need to brush up on your organic chemistry concepts, this book is here to help you navigate medicinal chemistry.
These are exemplified with a curated collection of concrete examples displayed in a highly visual “table-of-contents” style format, allowing readers to rapidly identify the most promising approaches applicable to their own challenges.
For many years, we stayed confident that solid‐phase combinatorial chemistry was one of them, and we believe that today this is more the case ... Combinatorial Strategies in Biology and Chemistry, John Wiley & Sons, ltd., West Sussex.
Another piece of the puzzle concerning the role of GR in RA is the discovery of a natural existing splice variant of GR, the GR. This protein represents a truncated version of GR (GR), that can translocate to the nucleus and bind to ...
With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical ...
The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices.
Emphasizing applications of chemistry while reinforcing theory -- especially in the areas of organic and physical chemistry -- this new text prepares students for career success in the pharmaceutical, medical, and biotech industries.
This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities...