Privileged Structures in Drug Discovery: Medicinal Chemistry and Synthesis

Description

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Get the book

Amazon.com

Search the book

eBay.com

Search the book

Other editions

• 

  Privileged Structures in Drug Discovery: Medicinal Chemistry and Synthesis

  • 2018-03-07
  • 560 pages
  • Ebook
  • John Wiley & Sons

Similar books

• 

  How Institutions are Shaping the Future of Our Children: For Better or for Worse?

  By Catherine Dulmus, Karen Sowers

  Lammert, M., & Timberlake, E. M. (1986). Termination of foster care for the older adolescent: Issues of emancipation and individuation.

• 

  Reversibility of Chronic Disease and Hypersensitivity, Volume 5: Treatment Options of Chemical Sensitivity

  By William J. Rea, Kalpana D. Patel

  Dou, L., E. Bertrand, C. Cerini, V. Faure, J. Sampol, R. Vanholder, Y. Berland, P. Brunet. ... A. Timberlake, B. Sumpio, R. Pfragner, I. M. Modlin, M. Kidd.

• 

  Rockwood and Green's Fractures in Adults

  By William Ricci, Charles M. Court-Brown, Margaret M. McQueen

  Chendrasekhar A, Moorman DW, Timberlake GA. An evaluation of the effects of ... Chittiboina P, Wylen E, Ogden A, et al. Traumatic spondylolisthesis of the ...

• 

  Breast Pathology, An Issue of Surgical Pathology Clinics

  By Laura C. Collins

  Hartmann LC, Radisky DC, Frost MH, et al. Understanding the premalignant potential of ... D'Alfonso TM, Wang K, Chiu YL, et al. Pathologic upgrade rates on ...

• 

  Telepractice in Speech-Language Pathology

  By K. Todd Houston

  Stensland, J., Speedie, S., Ideker, M., House, J., & Thompson, T. (1999). The relative cost of outpatient ... Deal, J. L. (1987). Appraisal and diagnosis of ...

• 

  Addressing Adversity: Prioritising adversity and trauma-informed care for children and young people in England.

  By Marc Bush, Lord Victor Adebowale, Rebecca Adlington

  1 2 Howard, S. and Johnson, B. (2000) Resilient and Non-resilient Behaviour in ... 4 De Haan, L., Hawley, D. and Deal, J. (2002) 'Operationalizing family ...

• 

  Culture, Brain, and Analgesia: Understanding and Managing Pain in Diverse Populations

  By Mario Incayawar, Knox H. Todd

  ... are not fluent in the language/s of the medical care provider.72 Research ... Anglo-Americans have traditionally placed a great deal of emphasis on the ...

• 

  Image-Guided Spine Interventions

  By John M. Mathis

  This practical guide thoroughly discusses both well-established and new interventions that are applied to the spine for the purpose of pain relief.

• 

  New Mynursinglab -- Access Card -- For Maternal-Child Nursing (24-Month Access)

  By Pearson Education, Pearson Education, Inc., David P Pearson Education

  Several versions of Pearson's MyLab & Mastering products exist for each title, including customized versions for individual schools, and registrations are not transferable.

• 

  Pearson's Medical Assisting (General)

  By Pearson Education Staff, Madan Dr Pearson Education

  If a picture paints a thousand words, imagine what video can do? Pearson Medical Assisting Videos help users learn the nuances and the details of many medical assisting procedures.