Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.
Reactions shown in Scheme 2.41 (opposite) exemplify the alternative approach involving an interaction between cationic intermediates generated from carbonyl compounds (or their derivatives) under the action of Lewis acids and a purely ...
The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, ...
More than any other branch of organic chemistry, synthesis has improved our understanding of the structure, dynamics, and transition of molecules. The availability of sophisticated tools and new techniques has...
... -NHZnCl2 in 339).240 Loss of an ammonium species by what is effectively an E1 process completes the synthesis of the indole ring (340). An application of the Fischer indole reaction is taken from Roberson and Woerpel's synthesis of ...
homogeneous catalysis refers to a catalytic process in which the catalyst and reagents are in the same phase, ... These processes are usually based on noble metal catalysts that are costly and whose abundance is very limited (Figure ...
References [1] D. C. Rideout and R. Breslow, J. Am. Chem. Soc. 102, 7816 (1980). [2] R. Breslow, U. Maitra. and D. C. Rideout, Tetrahcdron Lett. 24, 1901 (1983). ... 53, 3325, 3658 (1988), P. A. Grieco and S. D. Larsen, J. Org. Chem.
This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way.
The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the ...
The first edition of this book was welcomed with great enthusiasm by teachers and students.
Organic chemistry is one of the most rapidly developing of the sciences. Each year, there are new applications of organic compounds, for example, in medicine, in agriculture, and in the...