An integrated presentation of the basic science and clinical applications of anticancer agents Aimed at both undergraduate and postgraduate readers, this unique text provides readers with a fully-integrated presentation of all aspects of the science of anticancer drugs, including their chemistry, pharmacology, and clinical applications. After heart disease, cancer is the number one killer worldwide, and the tumor microenvironment is forever changing, creating an ever-greater demand for safer, more effective anticancer agents. In response to that demand, the $100 billion cancer drug market continues to grow, with our increased understanding of cancer leading to new drugs being used clinically almost every year. Anticancer Therapeutics is divided into three sections. Section 1 is an introduction to cancer and therapeutics, and covers the etiology and cellular and molecular basis of cancer. In Section 2, the authors focus on the anticancer agents — their discovery, synthesis, mode of action, mechanisms of resistance, and adverse reactions. Section 3 focuses on specific cancers, explaining how and why the various agents discussed in Section 2 are used, both individually and in combination, to treat different cancers. Integrates aspects of basic science, including chemistry and pharmacology and clinical medicine in relation to cancer therapeutics Written by an author team comprising specialists in medicinal chemistry, pharmacology, and oncology Features full-color images throughout illustrating how drugs bind to cellular targets and exert their pharmacological effect Divided into three sections, covering the etiology and cellular and molecular basis of cancer, anticancer agents, and drug applications for different cancers. Providing the reader with an integrated understanding of all aspects of the science of anticancer agents, this is an ideal textbook for undergraduates studying medicine, nursing, medicinal chemistry, pharmacy, pharmacology and other allied heath / life sciences. It is also a valuable bench reference for pharmacists, medics, and pharmaceutical researchers working in both academia and industry.
This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience.
S. Movassaghian, V.P. Torchilin, Long-circulating therapies for cancer treatment, in: Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies, Elsevier, 2015, pp. 433e462. M. Oishi, K. Kataoka, Y. Nagasaki, ...
This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, ...
Indispensable to the neuro-oncologist and useful to all physicians managing cancer patients, this book is a valuable source of current information.
Appels MMGM, Bolijn MJ, Chan K, Stephens TC, Hoctin-Boes G, et al. Br J Cancer 2008;98:1951. Reid TS, Beese LS. Biochemistry 2004:43:6877. Reid TS, Long SB, Beese LS. Biochemistry 2004:43:9000. Caponigro F, Casale M, Bryce J. Expert ...
This is also true for cancer, despite the aura of sanctity often of surrounding this dreaded disease and the apparent willingness the general population to spend large sums in this area and do "everything possible" for the patients.
This book represents a compilation of views and progress reports which illustrate the diversity of approaches to the problem. Recent research has confirmed the belief that critical genetic changes are at work in cancer cells.
In this Special Issue of Pharmaceuticals, we highlight the opportunities and challenges in the discovery and design of innovative cancer therapies, novel small-molecule cancer drugs and antibody–drug conjugates, with articles covering a ...
Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.
The fee code for users of the Transactional Reporting Service is: [0-89603-460-7/97 $8.00 + $00.25]. Library of Congress Cataloging-in-Publication Data Anticancer drug development guide: preclinical screening, clinical trials, ...