It has been realized for many years that cancer has a genetic component and at the level of the cell it can be said to be a genetic disease. In 1914, Boveri suggested that an aberration in the genome might be responsible for the origins of cancer. This was subsequently supported by the evidence that cancer, or the risk of cancer, could be inherited; that mutagens could cause tumors in both animals and humans; and that tumors are monoclonal in origin, that is, the cells of a tumor all show the genetic characteristics of the original transformed cell. It is only in recent years that the involvement of specific genes has been demonstrated at the molecular level. Molecular Biology of Cancer. Second edition is now in a larger format that has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. --
The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells.
This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment.
The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA.
Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
This volume explores some of the most exciting recent advances in basic research on the molecular biology of cancer and how this knowledge is leading to advances in the diagnosis, treatment, and prevention of cancer. * This series provides ...
Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features.
CancerMetastasis Rev.2005;24:47. 17 Lee JW, SoungYH,Kim SW, etal. Somaticmutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2005;11:2879. 18 Loeffler-Ragg J, Witsch-Baumgartner M, Tzankov A, etal.
This book summarizes the state, pitfalls, and potential of these efforts.
The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.
Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book.