Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
Taking an applied point of view, this book provides an accessible introduction to the theory of stationary random marked point processes on the non-negative real line.
3, e; * op(e | 0, X) (7.3.1) where T is some q x r parameter matrix, A-(I, & al.) is an rx's betweensubject design matrix with s = rq, 6 = Vec(T) and op(e |0, X) denotes some p-variate distribution (usually Gaussian) with mean 0 and ...
R, linear models, random, fixed, data, analysis, fit.
This practical, user-friendly reference/text integrates the latest theory, methodology, and applications related to the design and analysis of repeated measurements-covering a broad range of topics including the analysis of repeated ...
For more detailed discussions of Bootstrap methods, see Efron and Tibshirani (1993) and Davison and Hinkley (2006). 12.7 Matrix Algebra and Vector Differential Calculus For statistical models with more than one parameters, ...
... 509 Negative Negative Negative Positive 4 Negative Negative Positive Negative 17 Negative Negative Positive Positive 3 Negative Positive Negative Negative 13 Negative Positive Negative Positive 8 Negative Positive Positive Negative ...
Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory
From novice to professional: this book starts with the introduction of basic models and ends with the description of some of the most advanced models in longitudinal data analysis Enables students to select the correct statistical methods ...
statistical models to real data in social science research, including education and psychology. ... Her research work evaluates, using Monte Carlo simulations, innovative models as well as their applications in multilevel modeling and ...
One approach is to introduce random effects at each level to incorporate the withinlevel correlations and betweenlevel ... In pharmacokinetics and pharmacodynamics (PK/PD) modeling, the NONMEM package for fitting NLME models is popular.