Gene Transcription: Mechanisms and Control
- ISBN-10
- 1444311360
- ISBN-13
- 9781444311365
- Category
- Science
- Pages
- 288
- Language
- English
- Published
- 2009-04-01
- Publisher
- John Wiley & Sons
- Author
- R. J. White
Description
Transcription is the focus of much cutting-edge research, as befitsits essential place in biology. The established link betweendefects in gene transcription and many human disorders has fuelledconsiderable activity in the biomedical arena, particularly cancerresearch. This concentration of attention has uncovered a myriad offactors involved in transcription and the literature is now rifewith jargon and complexity. Gene Transcription: Mechanisms and Control aims todemystify the subject for a non-expert audience, providing a guidedtour around the complex machinery of the transcriptional apparatusand discussing how the various factors achieve their functions. Byfocusing on general principles and illustrating these with a selectgroup of examples, many of which are linked to human diseases, theauthor conveys the intricacies of transcriptional control in anaccessible manner. With the first chapter presenting an overview of geneexpression, this is a 'stand-alone' text, ideal for advanced levelundergraduates and postgraduates in biology, biochemistry andmedical sciences. It will also appeal to research scientists whorequire a broad current perspective on this rapidly moving andcomplex field. Provides a broad and accessible introduction to genetranscription. Up-to-date coverage of the major topics in a rapidly evolvingfield. Illustrates the links between aberrant transcription and humandisease. Explains the jargon associated with transcription factors.
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