Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions
- ISBN-10
- 1483145891
- ISBN-13
- 9781483145891
- Category
- Medical
- Pages
- 500
- Language
- English
- Published
- 2013-10-22
- Publisher
- Elsevier
- Author
- V. Claassen
Description
Techniques in the Behavioral and Neural Sciences, Volume 12: Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions can be used as reference in the improvement of test designs for biochemists and physiologists in the control of test conditions. The book is divided into five sections. The introduction deals with the uncertainty of animal characteristics and test conditions as hindrances to the development of general insight into biological regulatory mechanism. The first section discusses biopharmaceutics — the interaction of drugs when interacting with molecules or enzymes in sufficient concentration at a specific site of action. The second section reviews animal characteristics in terms of strain differences, sex differences, and changes during development and aging of the subject. The third section discusses the maintenance of experimental animals such as housing conditions, food composition, and water intake as these kinds of environmental factors may shape the phenotype and responsiveness of the experimental animal. The fourth section explains the testing conditions such as metabolic effects and drug interactions, anesthesia, stress, and even the effects on circadian rhythms. The last section is a discussion on the importance of experimental results. This section covers internal and external validities and statistical inference. The author concludes that the design of any experiment should include a power analysis so that reliable and valuable conclusions can follow. Biochemists, physiologists, pharmacokineticists, toxicologists, chemical researchers, and others for whom drugs are their main focus of study will find this book valuable.
Get the book
Other editions
-
- 1994
- 486 pages
- Paperback
- Elsevier Publishing Company
Similar books
-
Small Animal Imaging: Basics and Practical Guide
By Fabian Kiessling, Bernd J. Pichler, Peter HauffThis new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
-
Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research
By National Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal ResearchNational Research Council, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research. http://www.nap.edu/catalog/10732.html 2 ...
-
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research
By Wim E. Crusio, R.T. GerlaiCHAPTER 1.4 Experimental design and statistical inference Douglas Wahlsten Department of Psychology, University of Alberta, ... W. E. Crusio and R.T. Gerlai (Eds.) Handbook of Molecular-Genetic Techniques for Brain and Behavior Research ...
-
Handbook of Stress and the Brain Part 1: The Neurobiology of Stress
By Thomas Steckler, N.H. Kalin, J.M.H.M. ReulTopics covered in this book include: * An historical overview of the basic advances in stress research * The hypothalamic-pituitary-adrenal axis and hypothalamic hormones involved in stress coping * Neurotransmitter systems, neuroplasticity ...
-
Handbook of Stress and the Brain Part 2: Stress
By T. Steckler, N.H. Kalin, J.M.H.M. ReulThe Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes ...
-
Trends in Contrast Media
By Robert N. Muller, Henrik S. Thomsen, Robert F. MattreyWiley New York Claassen V (1994) Neglected factors in pharmacology and neuroscience research. Elsevier, Amsterdam Clough G (1982) Environmental effects on animals used in biomedical research. Biol Rev 57:487–523 Cunliffe-Beamer TL, ...
-
Handbook of Anxiety and Fear
By D. Caroline Blanchard, Guy Griebel, David J NuttNEUROSCIENCE. (formerly. Techniques ... ISBN 0-444-81369-1, Paperback ISBN 0-444-81674-7, Part 2, ISBN 0-444-81368-3, Paperback ISBN 0-444-81675-5 Neglected Factors in Pharmacology and Neuroscience Research, by V. Claassen (Ed.), 1994, ...
-
Handbook of Microdialysis: Methods, Applications and Perspectives
NEUROSCIENCE. (formerly. Techniques ... ISBN 0-444-81369-1, Paperback ISBN 0-444-81674-7, Part 2, ISBN 0-444-81368-3, Paperback ISBN 0-444-81675-5 Neglected Factors in Pharmacology and Neuroscience Research, by V. Claassen (Ed.), 1994, ...
-
Handbook of Episodic Memory
By Lynn Nadel, Alexander Easton, Ekrem DereThis book brings together a renowned team of contributors from the fields of cognitive psychology, neuropsychology and behavioural and molecular neuroscience.
-
Handbook of Laboratory Animal Science: Essential Principles and Practices
By Jann Hau, Steven J. SchapiroGreen, C.J. and Simpkin, S., Basic Microsurgical Techniques. A Laboratory Manual, Obtained from the Surgical Research Group, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, United Kingdom, 1990. 15.