The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept. The text also demonstrates phenotypic variability as a manifestation of translational control; and plasmacytomas. Molecular biologists, virologists, pathologists, cell biologists, oncologists, pharmacologists, and students taking related courses will find the book useful.
Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.
-- New to this edition: *New full colour diagrams help you visualize key concepts more effectively *Separate chapters for growing areas of cancer biology: Metastasis, Angiogenesis, Infectious Agents and Inflammation, and Technology and Drug ...
The text has been divided into two parts. Part I includes thirteen chapters that deal with the general principles of the molecular biology of cancer that provide the basic framework for an understanding of the behavior of cancer cells.
(1997)J.Natl Cancer Inst, 89, 1277. 9. Lagergren, J., Bergstrom, R. and Nyren, ... Lagergren, J., Bergstrom, R., Lindgren, A. and Nyren, O. (1999) N.Engl. J.Med., 340, 825. 11. ... Raskind, W.H., Norwood, T.H., Levine, D.S. et al.
Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
CancerMetastasis Rev.2005;24:47. 17 Lee JW, SoungYH,Kim SW, etal. Somaticmutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2005;11:2879. 18 Loeffler-Ragg J, Witsch-Baumgartner M, Tzankov A, etal.
Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features.
The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to ...
The Lucke ́ frog herpesvirus (RaHV-1) causes renal adenocarcinoma in the northern leopard frog, Rana pipiens. Interestingly, metastasis of this tumour occurs as a function of ambient temperature; frogs kept at 28 develop many metastases ...
The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.