Focusing on e-health and adolescents, this second issue of Adolescent Medicine: State of the Art Reviews is a stand-alone reference and practice tool. Topics in E-Health include: "Novel Implementations of Information Technology in Support of Adolescent Health Knowledge Acquisition," "Extending Electronic Health Records to Improve Adolescent Health," "Office-Based Computerized Risk-Assessment and Health Education Systems," "Secure E-mail Applications," "Examining and Using Emerging Technologies in Adolescent Health Research," "Application of Computer Technology to Adolescent Substance Abuse Prevention and Treatment," and "Engaging Youth in E-Health Promotion." "This is a very useful, timely, well organized collection of articles addressing the use of technology in adolescent healthcare. It should inspire both practitioners and researches alike to optimize and rethink their current practices." Julie Finger, MD, MPH, Tulane University School of Medicine, Doody's Review, 2009.