Cytokines and Chemokines in Infectious Diseases Handbook

Cytokines and Chemokines in Infectious Diseases Handbook
ISBN-10
1592593097
ISBN-13
9781592593095
Category
Medical
Pages
436
Language
English
Published
2003-03-03
Publisher
Springer Science & Business Media
Authors
Malak Kotb, Thierry Calandra

Description

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

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