Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval

Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval
ISBN-10
1592597394
ISBN-13
9781592597390
Category
Medical
Pages
451
Language
English
Published
2004-02-01
Publisher
Springer Science & Business Media
Authors
Beverly A. Teicher, Paul A. Andrews

Description

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Get the book

Amazon.com
Amazon.com
Search the book
eBay.com
eBay.com
Search the book

Other editions

Similar books

  • Anticancer Drug Development Guide
    Anticancer Drug Development Guide
    By Beverly A. Teicher

    Anticancer Drug Development Guide

  • Principles of Anticancer Drug Development
    Principles of Anticancer Drug Development
    By Elizabeth Garrett-Mayer, Manuel Hidalgo, S. Gail Eckhardt

    15.4.1.4 Determinants of Response to RTKTherapy Molecular determinants of TKI-based therapy may be different than that of monoclonal antibodies. EGFR mutations appear to determine the clinical efficacy of tyrosine kinase inhibitors.

  • Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
    Handbook of Anticancer Pharmacokinetics and Pharmacodynamics
    By William D. Figg, Howard L. McLeod, Michelle A. Rudek

    ... clinical pharmacology in order to optimize drug dose and schedule for their patients, to prospectively be aware of ... Melmon KL (2000) Introduction to clinical pharmacology and rational therapeutics. In: Carruthers GS, Hoffman BB ...

  • Handbook of Anticancer Drug Development
    Handbook of Anticancer Drug Development
    By Eric K. Rowinsky, Daniel Budman, A. Hilary Calvert

    Perhaps no area of pharmacology has progressed further or faster than that of anticancer drugs.

  • Animal Models in Cancer Drug Discovery
    Animal Models in Cancer Drug Discovery
    By Asfar Azmi, Ramzi M. Mohammad

    The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery.

  • Anticancer Drug Development
    Anticancer Drug Development
    By David J. Kerr, Bruce C. Baguley

    Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell ...

  • Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
    Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
    By MD, PhD, Ashkan Emadi

    From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology that are propelling new standards of care for common and uncommon ...

  • The Drug Development Paradigm in Oncology: Proceedings of a Workshop
    The Drug Development Paradigm in Oncology: Proceedings of a Workshop
    By Board on Health Care Services, Health and Medicine Division, Engineering

    BOX 5 Lung Cancer Master Protocol Trial Mary Redman, associate member of the Clinical Research Division at the Fred Hutchinson ... the Foundation for the National Institutes of Health (FNIH), a number of patient advocacy organizations, ...

  • In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
    In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
    By Dhanya Sunil, Raghu Chandrashekhar H, Pooja Kamath

    Key Features, Provides a user-friendly, one-stop, comprehensive and coherent foundation for in vitro anticancer drug development, An essential guide to young investigators starting a program on natural resources in the anticancer area from ...

  • Cancer Therapeutics: Experimental and Clinical Agents
    Cancer Therapeutics: Experimental and Clinical Agents
    By Beverly A. Teicher

    Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators...