Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65-120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS.
This book presents leading research from around the globe in this field.
This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states.
This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine ...
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Chemokines in Disease
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... chemokine receptors in breast cancer metastasis . Nature , 2001 410 , 50-56 . [ 218 ] Zlotnik A. Involvement of chemokine receptors in organ - specific metastasis . Contrib Microbiol , 2006 13 , 191-199 . [ 219 ] Kim J ; Mori T ; Chen ...
This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system. The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine.
... chemokine CCL21 in T - cell autoimmune diseases . Blood , 101 , 801-806 . [ 72 ] Romagnani , P. , Lasagni , L. , Annunziato , F. , Serio , M. , and Romagnani , S. ( 2004 ) . CXC chemokines : the regulatory link between inflammation and ...
... research see: CXCR7 impact on CXCL12 biology and disease. Trends In Molecular Medicine, 2013;19(1):12-22. (Elsevier - www.elsevier.c0m; Trends In Molecular Medicine - http: //www . elsevier . com/wps /product/cws_home/ 3 O 7 7 2) Our ...