The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.
This work focuses on recent contributions to the field of metastasis, and will highlight crucial findings in the molecular understanding of disseminated disease as well as standard and personalized medicine currently being investigated in ...
Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis.
According to the news reporters, the researchers concluded: “However, 26% of men can expect to retain sexual function at 5 ... Development of antimetastatic drugs that trigger or mimic the effect of metastasis suppressors represents new ...
While the initial motivation for these studies was the development of new diagnostic markers of metastasis, the biologic approach used to identify metastasis-suppressor genes has provided surprising insights into the in vivo mechanisms ...
According to recent research published in the International Journal of Cancer Journal International Du Cancer, ... “To investigate the efficacy of zoledronic acid (ZOL) on the development, progression and metastatic spread of OS, ...
In complement to bottom-up MS, recent advances in MS technology, such as high-field Fourier transform ion cyclotron ... and represses transcription of the tumor metastasis suppressor gene BRMSl Current study results from the report, ...
Previous findings have shown that KISS1 acts as a metastasis suppressor in numerous cancers in humans,” scientists ... “However, recent studies have demonstrated that an increase in KISS1 and GPR54 expression in human breast tumors ...
[ 297 ] Liu , Z. , Geboes , K. , Colpaert , S. , Overbergh , L. , Mathieu , C. , Heremans , H. , de Boer , M. , Boon , L. , D'Haens , G. , Rutgeerts , P. & Ceuppens , J.L. ( 2000 ) . Prevention of experimental colitis in SCID mice ...
According to recent research published in the journal Acta Crystallographica Section F, Structural Biology and Crystallization ... NDPK-A (or Nm23-H1), one of eight human NDPKs, acts as a metastasis suppressor for some tumor types.
Yu and colleagues published their study in Clinical Cancer Research (The EPHB6 receptor tyrosine kinase is a metastasis suppressor that is frequently silenced by promoter DNA hypermethylation in non-small cell lung cancer.