Airway Epithelium
- ISBN-10
- 1615043756
- ISBN-13
- 9781615043750
- Category
- Medical
- Pages
- 148
- Language
- English
- Published
- 2012-11-01
- Publisher
- Biota Publishing
- Author
- Jonathan Widdicombe
Description
The airways are lined with a film of fluid 10 μm deep that acts as the first line of defense against inhaled pathogens, dirt, and noxious vapors. Transepithelial fluid movements driven by active transepithelial ion transport serve to regulate the depth of this “airway surface liquid”. In the larger airways, a mucus gel derived from both glands and surface epithelium entraps inhaled particles, which are then removed by the coordinated beating of cilia. Both glands and epithelium secrete a wide variety of antimicrobial and other protective substances in addition to mucins. Substances released across the basolateral surface of the epithelium attract leukocytes and influence neighboring tissues. Here, after reviewing the basic structure of mammalian airway epithelium, I discuss its various defensive functions and how they are altered in airway disease.
Get the book
Similar books
-
The Pulmonary Neuroepithelial Body Microenvironment: A Multifunctional Unit in the Airway Epithelium
By Inge Brouns, Line Verckist, Isabel Pintelon... Lamas JA (2018) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS One 13:e0199282 Feyrter F (1938) Uber diffuse endokrine epitheliale Organe. In: Barth JA (ed) Barth, ...
-
Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease
By Venkataramana K Sidhaye, Michael KovalProc Natl Acad Sci USA 2011;108:14503À8. Haller T, Dietl P, Pfaller K, Frick M, Mair N, Paulmichl M, et al. Fusion pore expansion is a slow, discontinuous, and Ca21-dependent process regulating secretion from alveolar type II cells.
-
The Pulmonary Epithelium in Health and Disease
By David Proud"This is essential reading for everyone who would like to update their knowledge of the pulmonary epithelium.
-
The Airway Epithelium: Physiology, Pathophysiology, and Pharmacology
By Stephen FarmerIn 18 contributed chapters (including one by the editors), this reference discusses molecular, biochemical, physiological, and pharmacological roles of the epithelium both in healthy and diseased airways providing detailed descriptions of ...
-
Mucus Hypersecretion in Respiratory Disease
By Jamie A. Goode, Derek J. ChadwickThis book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem.
-
Immune Responses of the Mucosal Epithelium in Chronic Lung Diseases
By Loic Guillot, Marc Chanson, Christian HerrImmune Responses of the Mucosal Epithelium in Chronic Lung Diseases
-
Cilia and Mucus: From Development to Respiratory Defense
By Matthias SalatheThis book details advances in research regarding cilia, mucus, and mucociliary clearance, examining changes in mucus expression and goblet cell metaplasia, and assessing the ability of the mucociliary system to respond to abnormalities.
-
Severe Asthma
By Kian Fan Chung, Elliot Israel, Peter G. GibsonHow these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.