The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments. Table of Contents: Compartmentalization Is a Hallmark of Eukaryotic Cells / Organelles Can Be Classified Based on Their Origin / There Are Multiple Entry Points Into the Endomembrane System and a Network of Connecting Trafficking Routes / There Are Exceptions and Extensions to the Classic Trafficking Itineraries / A Mathematical Model Can Explain How Organelle Size Is Established and Maintained / Coats and SNAREs Constitute the Core Machinery for Vesicle Budding and Fusion / A Mathematical Model Explains How Coats and SNAREs Are Sufficient to Generate Organelle Identity / How Vesicle Formation Is Linked to Cargo Incorporation / RabGTPases Are the Master Regulators of Vesicular Traffic / The Mechanisms and Physiological Roles of Endocytosis / Models for Protein Transport in the Golgi Apparatus / Summary / Acknowledgments / References / Author Biography
The book contains color illustrations and charts; and the included CD-ROM contains dozens of video clips, animations, molecular structures, and high-resolution micrographs. Annotation copyrighted by Book News Inc., Portland, OR.
This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.
At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then?
This two-volume work surveys the major classes of GTPases, including their role in ensuring accuracy during protein translation, a new look at the trimeric G-protein cycle, the molecular function of ARF in vesicle coating, the emerging role ...
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students.
"Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells.
Vesicular Transport, Part A
Jentsch , T. , M. Poët , J. Fuhrmann , and A. Zdebik 2005 . Physiological functions of CLC Cl channels gleaned from human genetic disease and mouse models . Ann . Rev. Physiol . 67 : 779–807 . Jiang , Y. , et al . 2003.
This book is aimed at a broad readership of glycobiologists as well as cell and molecular biologists and may also be interesting for advanced students of biology and life sciences.