Antibiotics: Challenges, Mechanisms, Opportunities
- ISBN-10
- 168367331X
- ISBN-13
- 9781683673316
- Series
- Antibiotics
- Category
- Medical
- Language
- English
- Published
- 2016-02-01
- Publisher
- John Wiley & Sons
- Authors
- Christopher Walsh, Timothy Wencewicz
Description
A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Get the book
Other editions
Similar books
-
Antibiotics Simplified
By Gallagher, Conan MacDougallThis text simplifies learning infectious disease pharmacotherapy and condenses the many facts that are taught about antibiotics into one quick reference guide.
-
Chemistry of Antibiotics and Related Drugs
By Mrinal K. BhattacharjeeThis textbook discusses how the various types of antibiotics and related drugs work to cure infections.
-
Miracle Cure: The Creation of Antibiotics and the Birth of Modern Medicine
By William RosenWilliam Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters.
-
Herbal Antibiotics, 2nd Edition: Natural Alternatives for Treating Drug-resistant Bacteria
By Stephen Harrod BuhnerYoshida, N., et al. ... Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol 302, no. 2 (2002): 645–50. ... The role of CYP3A4 and p-glycoprotein in food-drug and herb-drug interactions.
-
Antibiotics: Origin, Nature and Properties
By Tadeusz Korzybski, Zuzanna Kowszyk-Gindifer, Wlodzimierz KurylowiczThis book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources.
-
Antibiotics and Antibiotic Resistance
By Ola SköldThis book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance.
-
Antibiotics and Antibiotic Resistance in the Environment
By Carlos F. Amabile-CuevasThis book reviews the available evidence and hypotheses on where this resistance is coming from and for how long it has been there; what are the effects of the continuous release of antibiotics into the environment; what are the selective ...
-
Antibiotic Basics for Clinicians
By Alan R. HauserAntibiotic Basics for Clinicians, South Asian Edition, simplifies the antibiotic selection process for the clinicians with up-to-date information on the latest and most clinically relevant antibacterial medications.
-
Antibiotics: Methods and Protocols
By Peter SassThis volume provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, and methods for the analysis and detection of microbial adaptation strategies.
-
Antibiotics: What Everyone Needs to Know®
By Mary E. WilsonVirtually everyone has taken antibiotics. They can be lifesavers -- and they can be useless. What are they? How are they used? And what happens as the effectiveness of antibiotics continues to decline?