Without optimism there is no hope, without resilience there is no achievement, and without gratitude there is no joy. The 25 women featured in this compilation of autobiographic vignettes are the embodiment of this passage. You will become immersed in their courageous journeys as they overcome seemingly insurmountable obstacles to make lasting achievements in their fields. With the support of their loved ones and mentors, when faced with encumbering influences and harmful stereotypes, they showed the humility and resilience needed to become leaders in academic medicine.