Integrative Pharmacology-based Research on Traditional Medicine: Methodologies, Medical and Pharmacological Applications
- ISBN-10
- 2832535518
- ISBN-13
- 9782832535516
- Category
- Science
- Pages
- 1019
- Language
- English
- Published
- 2023-09-19
- Publisher
- Frontiers Media SA
- Authors
- Yan Xu, Hai Yu Xu, Chang-xiao Liu
Description
ntegrative Pharmacology can be used to determine the multi-pharmacological effects of traditional medicines such as traditional Chinese medicine (TCM), Kampo, Sa-sang, Ayurveda, etc.). Through qualitative and quantitative pharmacokinetic-pharmacodynamic (PK-PD) correlations among multi-constituents and multi-targets, integrating chemical profiling, ADME/PK processes, molecular network calculation and resulting experimental validation, the use of Integrative Pharmacology has become widespread. The data has provided a novel paradigm to evaluate the druggability of bioactive ingredients of herbs or formulae, to decipher the pharmacological mechanisms of drug action and to screen potentially new indications for approved drugs and previously unidentified adverse events. On this basis, Integrative Pharmacology may offer an effective way to test the potential scientific basis for traditional medicines and to assess what roles of traditional medicine can and cannot play in pharmaceuticals.
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