Neuropeptide GPCRs in neuroendocrinology

Neuropeptide GPCRs in neuroendocrinology
ISBN-10
2889192679
ISBN-13
9782889192670
Category
Diseases of the endocrine glands. Clinical endocrinology
Pages
826
Language
English
Published
2014-11-07
Publisher
Frontiers E-books
Authors
Hubert Vaudry, Jae Young Seong

Description

The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.

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