The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
Neurological and psychiatric disorders can occur in endocrine diseases either in the setting of the clinical manifestations of the same (i.e., hyper- or hyposecretion of hormones or peptides from the endocrine glands) or as events secondary ...
Anti-social behaviors and social deficits induced mental disorders are critical problems in our society today.
Br. J. Psychiatry 128, 379–383. doi: 10.1192/bjp.128.4.379 Oates, M. (2003). Suicide: the leading cause of maternal death. Br. J. Psychiatry 183, 279–281. doi:10.1192/bjp.183.4.279 O'Hara, M. W., Stuart, S., Gorman, L. L., and Wenzel, ...
This book has been written by widely acknowledged experts, with each chapter providing unique information on emerging aspects of T1D.
About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control.
Neuroendocrinology is the discipline that investigates the interplay between the nervous and endocrine systems i.e. the control of endocrine glands by the central and peripheral nervous systems, the action of hormones on nerve cells and the ...