Cellular and Phenotypic Plasticity in Cancer
- ISBN-10
- 2889196623
- ISBN-13
- 9782889196623
- Category
- Cancer
- Pages
- 79
- Language
- English
- Published
- 2015-09-17
- Publisher
- Frontiers Media SA
- Authors
- Robin Anderson, Andreas Behren, Petranel Theresa Ferrao
Description
The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies.
Get the book
Similar books
-
Biomedical Physics in Radiotherapy for Cancer
By Eva Bezak, Loredana Marcu, Barry AllenKing TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG and Jiang XZ (2000) Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) ...
-
Medical Care of Cancer Patients
By Sai-Ching Jim Yeung, Carmen P. Escalante, Robert F. GagelYeung C , May J , Hughes R. Infection rate for single - lumen vs triple - lumen subclavian catheters . Infect Control Hosp Epidemiol 1988 ; 9 : 154–8 . 59. Mantese VA , German DS , Kruminski DL , et al . Colonization and sepsis from ...
-
A Perfect 10: Phyto "New-trients" Against Cancers
By Laura PawlakHawrylewicz EJ , Huang HH , et al : Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats . J. Nutr . 121 : 1693-1698 , 1991 . Holmberg L : Diet and breast cancer risk . Arch . Intern . Med .
-
The Apocalyptics: How Environmental Politics Controls what We Know about Cancer
By Edith EfronInterviews by Pamela Wharton Blanpied , Research Assistant to Edith Efron , October 10 and 14 , 1980 . Roy Albert , Lecture , Seminar on Government Regulation of Cancer - Causing Chemicals , sponsored by the National Center for ...
-
The Strang Cookbook for Cancer Prevention: A Complete Nutrition and Lifestyle Plan to Dramatically Lower Your Cancer Risk
By Laura J. Pensiero, Susan OliveriaDescribes the dietary risks of cancer, and offers healthy recipes
-
Dying Was Easy: Laughter, Tears, Anger and Cancer
By Stephen Craig ZinckSK I am still amazed that people actually read my posts and made a connection in some way I just wrote what I was feeling at the time Yet, strangers responded with support and stories of their own One such response came from Todd He had ...
-
The Sufferings of the Cancer Patient. [By] Vera M. Naylor and David Michaels
By David Michaels, Vera Mary NaylorThe Sufferings of the Cancer Patient. [By] Vera M. Naylor and David Michaels
-
Portraits in Courage: Extraordinary Lessons from Everyday Heroes
By Dave Dravecky, Jan Dravecky, Steve HallidayWhen it became known that Andrew Johnson , then nine years old , would lose his leg because of a cancerous tumor , two women - one a nurse , the other a school guidance counselor - called to ask us to contact Andrew's parents .
-
Intensity Modulated Radiation Therapy: A Clinical Perspective
By Arno J. Mundt, John C. RoeskeSpence AM , Muzi M , Graham MM , et al . 2 - [ ( 18 ) F ] Fluoro - 2deoxyglucose ... Sato N , Suzuki M , Kuwata N , et al . Evaluation of the malignancy of glioma ... Valk PE , Mathis CA , Prados MD , et al . Hypoxia in human gliomas ...
-
The Child with Cancer: Nursing Care
By Jenny ThompsonCharlton A , Pearson D and Morris Jones PH ( 1986 ) Children's return to school after treatment for solid tumours . Society of Scientific Medicine : 22 : 1337-1346 . Cobb B ( 1956 ) Psychological impact of long - term illness and death ...