Purpose of In vivo Models of Inflammation is to provide the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. The aim of this second edition is to act as a complement to the first by describing and updating the standard models that are most utilized for specific disease areas. In addition, this 2nd edition includes new models exploring emerging areas of inflammation research. It provides detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. New approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has also been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. The book provides the scientist with an up-to-date reference manual for selecting the best animal model for their specific question. Chapters describing current regulations in the United States, United Kingdom, and Japan are also included.
Talks about in vivo models of inflammation.
Though researchers have progressively unr- eled the mechanisms, the story is far from complete.
This volume provides a broad spectrum of research models, techniques, and protocols.
The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, ...
Offering a comprehensive overview of laboratory research models and practical experimental protocols used in the study of inflammation, this volume discusses the development and therapeutic evaluation of new anti-inflammatory and anti ...
The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
The book describes a protocol to evaluate anti-inflammatory activity in popular animal models along with biochemical and molecular pharmacological investigations.
This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations ...
A comprehensive review of recent medicinal chemistry approaches to a variety of important therapeutic targets and a key reference for those interested in the prosecution of modern drug discovery programs directed at anti-inflammatory ...
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer.