Alzheimer's Disease: Challenges for the Future

Alzheimer's Disease: Challenges for the Future
ISBN-10
9535121375
ISBN-13
9789535121374
Series
Alzheimer's Disease
Category
Medical
Pages
372
Language
English
Published
2015-07-01
Publisher
BoD – Books on Demand
Author
Inga Zerr

Description

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.

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