Selected Papers of Frederick Sanger: With Commentaries
- ISBN-10
- 9810224303
- ISBN-13
- 9789810224301
- Category
- Science
- Pages
- 662
- Language
- English
- Published
- 1996
- Publisher
- World Scientific
- Authors
- Frederick Sanger, Margaret Dowding
Description
This important volume is mainly concerned with the development of methods for ?sequencing? ? that is, determination of the order of the amino acids in proteins and of nucleotides in RNA and DNA. In 1943 the position of only one amino acid in a protein (insulin) was known, and Sanger's first paper resulted in finding a second amino acid. In his final paper in 1982 he describes the determination of a DNA sequence of 48,502 nucleotides. The papers describe the steady improvements in techniques, and exciting biological results revealed by the sequences.
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