Neural Crest Stem Cells: Breakthroughs and Applications
- ISBN-10
- 9814460591
- ISBN-13
- 9789814460590
- Category
- Science
- Pages
- 168
- Language
- English
- Published
- 2012-04-26
- Publisher
- World Scientific
- Author
- Maya Sieber-Blum
Description
The book offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. The neural crest is a transient tissue of the vertebrate embryo. It originates from the future spinal cord and neural crest stem cells emigrate from this location to various places in the embryo, giving rise to many different cell types and tissues. Neural crest derivatives include the peripheral nervous systems, endocrine cells such as the adrenal medulla, smooth musculature of the cardiac outflow tract and great blood vessels, as well as craniofacial bone and cartilage. The underlying mechanisms that regulate embryonic neural crest development are still being investigated and are important for our understanding of neural crest pathologies. Readers will have ready access to current research topics, elaborated in great detail, with a focus on adult neural crest-derived stem cells, which persist in various locations of the postnatal organism. Delving into stem cells from different locations of the body, the book explores the best possible source of such cells for future use in medical applications. Contents:Regulation of Embryonic Neural Crest Cell Differentiation:The New Heart for the New Head (Deborah J Henderson and Bill Chaudhry)Dual but Converging Roles: A Tale of Two Crests (Michael Olaopa and Simon J Conway)The Cornea, Neural Crest and Stem Cells (Charles Osei-Bempong, Haifa Ali and Sajjad Ahmad)Adult Neural Crest Stem Cells:Characterisation of Neural Crest-Derived Stem Cells in Different Tissues (Narihito Nagoshi and Hideyuki Okano)Epidermal Neural Crest Stem Cells (Oliver Clewes and Maya Sieber-Blum)Neural Crest Stem Cells from the Head Region (Christian Kaltschmidt and Barbara Kaltschmidt) Readership: Postgraduate students, researchers and professionals interested in stem cells and developmental biology research. Keywords:Neural Crest;Stem Cell;Somatic Stem Cell;Adult Stem Cell;Embryonic Stem Cell;Multipotency;Induced Pluripotent Stem Cells (iPS Cells);Heart;Cardiac Outflow Tract;Tooth;Dental Pulp;Bone Marrow;Adrenal Medulla;Dorsal Root Ganglion;Craniofacial;BoneKey Features:Large market for applications in cell replacement therapy and biomedical engineeringUseful study material for academicsUseful information for the pharmaceutical industry
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