A Biography of Paul Berg: The Recombinant DNA Controversy Revisited

A Biography of Paul Berg: The Recombinant DNA Controversy Revisited
ISBN-10
9814569062
ISBN-13
9789814569064
Category
Science
Pages
444
Language
English
Published
2014-06-17
Publisher
World Scientific
Author
Errol C Friedberg

Description

With a Foreword writer Sydney Brenner (Nobel laureate in Physiology or Medicine, 2002) This biography details the life of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's life from birth, in 1926, to the present, with special emphasis on his enormous scientific contributions, including being the first to develop technology that led to gene cloning science. In 1980, Berg received a Nobel Prize in chemistry for this work. In addition to his contributions in the research laboratory, Berg orchestrated and oversaw a historic meeting at Asilomar, California that centered on a threatening controversy surrounding the perception by some of the harmful potential of recombinant DNA technology. This meeting did much to forestall this controversy and to put in place the regulation of recombinant DNA work, thus putting fears to rest. The recombinant DNA controversy was a historic outcome of the discovery of gene cloning. Notably, it represented a paramount example of scientific foresight and due diligence by the scientific community, rather than by regulatory entities in the United States and many other countries. The ultimate acceptance of gene/DNA cloning led to a new era of modern biology that thrives to the present. This book is aimed primarily at scientists and those in training. The book strives to simply provide information for the general reader, but is not specifically tailored for a general reading audience. While many books cover the recombinant DNA controversy, none have satisfactorily addressed this historic period and are often contradictory about the many who's, where's, and why's involved. Additionally, the great majority of these were written by non-scientists. This biography of Paul Berg provides access to numerous archived letters and documents at Stanford University not previously addressed, and to the chronology of events as recalled and documented by him, as well as other key personalities, many of whom were interviewed. Contents:Part I:Growing Up in BrooklynThe Essential Paul BergCollege — and World War IIWestern Reserve UniversityCopenhagenPart II:Washington University, St. LouisDiscovering Transfer RNAStanford University — and Its Refurbished Department of BiochemistryTranscription and Translation: New DirectionsPart III:Making Recombinant DNA — The First Faltering StepsMaking Recombinant DNA — A Major BreakthroughEcoRI Restriction Endonuclease — A Major Breakthrough“Coincidence is the Word We Use When We Can't See the Levers and Pulleys”Yet Another Stanford ContributionPart IV:An Historic Meeting in HawaiiThe Recombinant DNA ControversyA Momentous Gordon Research ConferenceMaking Recombinant Molecules with Frog DNAThe Controversy Heats UpAsilomar IIThe Dissenters: A Different Point of ViewThe AftermathLegislative and Revisionist Challenges to Recombinant DNAAsilomar II — Lessons LearnedPart V:The Nobel Prize in ChemistryCommercializing the TechnologyLife Goes onThe “Retirement” YearsPublic Policy Issues — and Other InterestsPersonal Challenges Readership: Researchers, graduate students, undergraduates in life sciences, medicine and chemistry and interested lay public. Keywords:Recombinant DNA;Paul Berg;Stanford University;Errol Friedberg;DNA;tRNA;Asilomar Meeting Western Reserve University;Stanley Cohen Gene Cloning;Nobel PrizeReviews: “This is a great and very readable story of a renowned biochemist moving outside his comfort zone to provide needed leadership at a time of national turmoil. Friedberg takes us from Berg's beginnings in Brooklyn in an immigrant Yiddish-speaking family to his receipt of the Nobel Prize. He also describes Berg's guidance of a process of public acceptance of a revolutionary scientific advance — Recombinant DNA technology — that appeared to be hazardous because it was so innovative. The book reads easily, with enough technical discussion to be informative without being too demanding. It also includes an insightful investigation of the mystery of who actually deserves credit for making the technology a reality, which will fascinate other scientists and anyone who cares about the history of science and technology.” David Baltimore Nobel Laureate “Friedberg's book is a valuable addition to the literature on the scientific development of recombinant DNA technology, particularly the interactions among the numerous scientists involved who jockeyed for priority. It also details the life and times of one of the most outstanding biochemists this country has ever produced. ” DNA Repair

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