Antibody Fc
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Antibody Fc: Chapter 13. Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer
By Marije B. Overdijk, Sandra Verploegen, Wim K. BleekerCarlotti E, Palumbo GA, Oldani E, et al. FCgammar IIIA and Fcgammar IIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab. Haematologica.
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Antibody Fc: Chapter 4. Natural Killer Cells
By Andreas DiefenbachNatural killer (NK) cells are granular lymphocytes that play important roles in immunity against viruses and in the immune surveillance of tumors.
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Antibody Fc: Chapter 7. Structural Recognition of Immunoglobulins by Fcγ Receptors
By Peter SunThis review summarizes the structural findings that formed the basis of modern antibody–Fc receptor biology and recent advances of shared Fc receptor recognition by innate pentraxins.
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Antibody Fc: Chapter 9. Human IgG Subclasses
By Theo Rispens, Gestur VidarssonImmunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate.
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Antibody Fc: Chapter 16. Fcγ Receptors as Therapeutic Targets
By Robert M. AnthonyIn fact, the effector functions triggered by IgG antibodies are highly dependent on the type of Fc receptor that is bound; however, many aspects can influence Fc receptor binding by IgG antibodies, including the IgG isotype and the ...
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Antibody Fc: Chapter 17. Fc Protein Engineering
By Roy JefferisDiversity of antigen-binding specificity may be considered the hallmark of antibodies; however, the human IgG-Fc region also exhibits binding specificity for multiple ligands.
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Antibody Fc: Chapter 10. Antibody Glycosylation
By Xiaojie Yu, Kavitha Baruah, Christopher N. ScanlanThe antibody Fc region is posttranslationally modified by N-linked glycosylation.
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Antibody Fc: Chapter 1. Antibody-Dependent Cellular Cytotoxicity (ADCC)
By Victor Raúl Gómez Román, Joseph C. Murray, Louis M. WeinerAntibody-dependent cellular cytotoxicity (ADCC), also called antibody-dependent cell-mediated cytotoxicity, is an immune mechanism through which Fc receptor-bearing effector cells can recognize and kill antibody-coated target cells ...
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Antibody Fc: Chapter 8. FcγRs Across Species
By Brian Moldt, Ann J. HessellAntibody Fc: Chapter 8. FcγRs Across Species
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Antibody Fc: Chapter 15. Fc Receptor-Dependent Immunity
By Joseph U. Igietseme, Xiaoping Zhu, Carolyn M. BlackDeleterious immune reactivity associated with FcR engagement, including immune complex diseases, allergic reactions due to IgE-mediated activation of mast cells and basophils, or facilitation of microbial infectivity, such as antibody ...
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Antibody Fc: Chapter 3. Interactions Between the Complement System and Fcγ Receptors
By Margaret A. Lindorfer, Jörg Köhl, Ronald P. TaylorThe key roles of the complement cascade and cellular Fcγ receptors in the innate and adaptive immune system are well documented.
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Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in Autoimmune Disorders
By Falk NimmerjahnThis review summarizes these data and explains how this information might be used to better understand human autoimmune diseases and to develop novel therapeutic strategies.
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Antibody Fc: Chapter 19. Pathogenic Exploitation of Fc Activity
By Scott B. HalsteadThis chapter reviews the literature of ADE in relation to the innate immune responses to Fcγ receptor ligation by infectious IgG immune complexes and discusses the research frontiers regarding this harmful antibody activity.
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Antibody Fc: Chapter 12. Fcγ Receptor Polymorphisms and Susceptibility to Infection
By Menna R. ClatworthyFcγ receptors (FcγR) mediate many effector functions of antibody and are critical for defense against pathogens, including bacteria, viruses, and parasites.
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Antibody Fc: Chapter 14. No Mechanism is an Island: Interactions Among Monoclonal Antibody Mechanisms of Action
By George J. WeinerMonoclonal antibodies (mAbs), including rituximab, are now a mainstay in the therapy of cancer.
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Antibody Fc: Chapter 6. B Cells: Development, Differentiation, and Regulation by Fcγ Receptor IIB in the Humoral Immune Response
By Elizabeth R. Walsh, Silvia BollandBecause of the ever-increasing number of pathogenic organisms and their rapid mutation rates, the humoral immune system must have the ability to adapt and change along with evolving pathogens.
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Antibody Fc: Chapter 5. Phagocytes and Immunoglobulins
By Luisa Martinez-PomaresThis chapter offers an overview of the basic biology of phagocytes, macrophages, dendritic cells, and neutrophils and how it is affected by receptors for the Fc portion of antibodies (FcRs), particularly FcγRs.
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Antibody Fc: Chapter 18. Bacterial Modulation of Fc Effector Functions
By Mattias Collin, Mogens KilianImmunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections.
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Antibody Fc: Linking Adaptive and Innate Immunity
By Margaret Ackerman, Falk NimmerjahnAntibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response.