Drug Discovery and Evaluation

  • Drug Discovery and Evaluation: Pharmacological Assays
    Drug Discovery and Evaluation: Pharmacological Assays
    By Hans Vogel

    The Z-factor and the Z' factor were introduced to characterize the reliability of high-throughput assays (Zhang et al. 1999, 2000b). The Z-factor is a dimensionless, simple statistical characteristic, which reflects the assay signal ...

  • Drug Discovery and Evaluation: Pharmacological Assays
    Drug Discovery and Evaluation: Pharmacological Assays
    By Hans G. Vogel, Wolfgang H. Vogel

    This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, ...

  • Drug Discovery and Evaluation: Pharmacological Assays
    Drug Discovery and Evaluation: Pharmacological Assays
    By Hans G. Vogel

    REFERENCES Litchfield JT Jr., Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. ... a 23-gauge needle is then introduced through the superior rectus muscle, tangentially to the globe, and is immobilized as ...

  • Drug Discovery and Evaluation: Methods in Clinical Pharmacology
    Drug Discovery and Evaluation: Methods in Clinical Pharmacology
    By H.Gerhard Vogel, Jochen Maas, Alexander Gebauer

    These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies.

  • Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays ; with 125 Tables
    Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays ; with 125 Tables
    By Jochen Maas, H. Gerhard Vogel

    The bleeding time of the mesenteric blood vessels is observed through a microscope at a magnification of 40 ×. ... Br J Haematol 50:317–325 I.M.4.3 Template Bleeding Time Method PURPOSE AND RATIONALE The template bleeding time method is ...

  • Drug Discovery and Evaluation: Pharmacological Assays
    Drug Discovery and Evaluation: Pharmacological Assays
    By Franz J. Hock

    In addition, animal models of rare diseases are described. For this 4th edition, all existing chapters have been revised and completely updated. A large number of assays were added.

  • Drug Discovery and Evaluation: Methods in Clinical Pharmacology
    Drug Discovery and Evaluation: Methods in Clinical Pharmacology
    By H.Gerhard Vogel, Jochen Maas, Alexander Gebauer

    These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies.

  • Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
    Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
    By Jochen Maas, Dieter Mayer, H. Gerhard Vogel

    -A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for ...